| MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemia. | leukemia, |
| The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene. | None |
| Data show that the AF6 RA1 domain efficiently mediated self-association, suggesting that constitutive MLL self-association is a more common pathogenic mechanism for MLL oncogenesis than indicated by previous studies of rare MLL fusion partners. | None |
| Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6. | None |
| Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l. | None |
| Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l. | None |