| The Nrf2 signaling pathway in normal cells maintains the cellular environment, and genomic stability and acts a tumor suppressing gene.Nrf2 promotes tumor growth and enhances drug resistance in ovarian cancer.[review] | ovarian, |
| Results show that oncogenic Nrf2 mutation induces dependence on the mTOR pathway during carcinogenesis. | None |
| Deregulation of Nrf2 due to mutations may lead to nuclear accumulation of Nrf2 that reduces apoptosis and promotes oncogenesis and drug resistance. [Review] | None |
| The oncogenic functions of Nrf2. [review] | None |
| This review summarizes some of the known mechanisms by which NRF2 can exert its oncogenic functions, and describes the current status of NRF2 inhibitors, providing a clear rationale for the consideration of NRF2 as a powerful putative therapeutic target in cancer treatment. [review] | None |