| results indicate that NOTCH serves as a tumor suppressor in the bladder and that loss of this pathway promotes mesenchymal and invasive features. | bladder, |
| NOTCH2 acts as an oncogene that promotes bladder cancer growth and metastasis through epithelial-to-mesenchymal transition, cell-cycle progression, and maintenance of stemness. Inhibition of NOTCH2 is a rational novel treatment strategy for invasive bladder cancer. | bladder, |
| Review of the roles of NOTCH1 and NOTCH2 in urinary bladder cancer suggests that NOTCH1 acts as a tumor suppressor and NOTCH2 acts as an oncogene that promotes cell proliferation and metastasis through epithelial-to-mesenchymal transition, cell cycle progression, and maintenance of stemness. | bladder, |