| Geldamycin-sensitive interactions with Hsp90 are critical for both TrkAI tumour suppressor and TrkAIII oncogenic function in neuroblastoma. | neuroblastoma, |
| Search for NTRK1 proto-oncogene rearrangements in human thyroid tumours originated after therapeutic radiation. | thyroid, |
| Ribosomal protein L7a gene is up-regulated but not fused to the tyrosine kinase receptor as chimeric trk oncogene in human colorectal carcinoma. | colorectal, |
| TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. | thyroid, |
| Rearrangements of NTRK1 oncogene in papillary thyroid carcinoma. | thyroid, |
| Geldamycin-sensitive interactions with Hsp90 are critical for both TrkAI tumour suppressor and TrkAIII oncogenic function in neuroblastoma. | neuroblastoma, |
| The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells. | neuroblastoma, |
| Data suggest that diet factors (i.e., olive pomace polyphenols) up-regulate NGF/TrkA (proto-oncogene trk) and BDNF/TrkB (brain derived neurotrophic factor/receptor) in hippocampus/olfactory bulb and down-regulate NGF/BDNF in frontal cortex/striatum. | brain, |
| Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer. | lung, |
| Tumor samples from 3 of 91 patients with lung cancer (3.3%) without known oncogenic alterations assayed by next-generation sequencing or fluorescence in situ hybridization demonstrated evidence of NTRK1 gene fusions. | lung, |
| The TrkAIII oncoprotein inhibits mitochondrial free radical ROS-induced death of SH-SY5Y neuroblastoma cells by augmenting SOD2 expression and activity at the mitochondria, within the context of a tumour stem cell-like phenotype. | neuroblastoma, |
| TrkA as a candidate oncogene in malignant melanoma and support a model in which the NGF-TrkA-MAPK pathway may mediate a trade-off between neoplastic transformation and adaptive anti-proliferative response. | skin, |
| Report a novel subset of high-grade uterine sarcomas with features reminiscent of soft tissue fibrosarcoma and characterized by oncogenic activation of Trk through recurrent NTRK gene fusions. | fibrosarcoma,uterine, |
| Rearrangements of TRK proto-oncogene in papillary thyroid carcinomas. | thyroid, |
| Induction of nerve growth factor responsiveness in C6-2B glioma cells by expression of trkA proto-oncogene. | glioma, |
| Role of the TFG N-terminus and coiled-coil domain in the transforming activity of the thyroid TRK-T3 oncogene. | thyroid, |
| Molecular cloning and characterization of the 5 region of the mouse trkA proto-oncogene. | None |
| IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1. | None |
| Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains. | None |
| Deregulated expression of interferon regulatory factor-1 in oncogene-transformed mouse fibroblasts. | None |