| Parkin, implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27 in breast asnd ovarian cancers. | breast,ovarian, |
| This gene, implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27 in breasssssst asnd ovarian cancers. | ovarian, |
| analysis of Parkin protein expression with antibodies revealed that most of the ovarian cancer cell lines and primary tumors had diminished or absent Parkin expression and it is suggested it may be a tumor suppressor gene | ovarian, |
| Parkin is a tumor suppressor gene whose inactivation may play an important role in non-small cell lung cancer tumorigenesis | lung, |
| candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm | leukemia,neoplasm, |
| Parkin as a tumor suppressor gene for hepatocellular carcinoma. | liver, |
| Allelic loss of 6q25-27, the PARKIN tumor suppressor gene locus, in cervical carcinoma. | cervical, |
| Parkin is a tumor suppressor gene whose inactivation may play an important role in the carcinoma of uterine cervix. | uterine, |
| our study provides mechanistic insight into the tumor suppressor function of parkin in brain tumors | brain, |
| The parkin protein acts as a tumor suppressor in human cervical cancer cells by modulating survivin expression and caspase activity. | cervical, |
| Results show an important role for PARK2 as a tumor suppressor both in melanoma predisposition and progression, which could explain the molecular mechanism behind the epidemiological association of melanoma and Parkinson disease. | skin, |
| Findings suggest that PARK2 might have a tumor suppressor role in the development of chronic obstructive pulmonary disease (COPD) and lung cancer. | lung, |
| Our study provided sufficient information and insight for investigation of PARK-2 and highlighted its role as a tumor suppressor gene in cervical cancer in North Indian population | cervical, |
| Parkin expression is inversely correlated with HIF-1alpha expression and metastasis in breast cancer. Results reveal an important mechanism for Parkin in tumor suppression and HIF-1alpha regulation. | breast, |
| Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells. | lung, |
| Data strongly point to PARK2 as a tumor suppressor on 6q25.2-q27. | None |
| Data indicates that Parkin regulates mitotic progression and its deficiency results in multiple mitotic defects, genomic instability, and tumorigenesis suggesting a role as tumor suppressor. | None |