| Par-4 is a relevant tumor suppressor gene in human endometrial carcinogenesis. | endometrial, |
| Results suggest that, in breast cancer, Par-4 plays a similar tumor suppressor gene role as reported in endometrial carcinoma, and that Par-4 expression has a significant inverse association with expression of progesterone receptor. | breast,endometrial, |
| Down-regulation of the candidate tumor suppressor gene PAR-4 is associated with poor prognosis in breast cancer. | breast, |
| Chronic lymphocytic leukemia (CLL) cells overexpress a well-defined tumor suppressor Par-4, which promotes malignant B-CLL growth and is regulated through B-cell receptor signaling. | leukemia, |
| Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer | breast, |
| These findings suggest that PAR4 plays a potential tumor suppressor role in esophageal squamous cell carcinoma cells | esophageal, |
| Par-4 is a tumor suppressor protein with a pro-apoptotic function. Epigenetic silencing of Par-4 is seen in diverse tumors, [REVIEW] | None |
| The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. | None |
| The Ras effector RASSF2 controls the PAR-4 tumor suppressor. | None |
| The addition of TRAIL to WIN 55.212-2-treated cells led to apoptotic death probably mediated by up-regulation of the tumor suppressor factor PAR-4, whose levels increased after WIN treatment, and by the translocation of GRP78 on cell surface. | None |
| Tetramer formation by the caspase-activated fragment of the Par-4 tumor suppressor | None |
| A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms_ tumor suppressor WT1. | None |