| detected deletion of the ING4 locus in 10-20% of human breast cancer cell lines and primary breast tumors, supporting the possibility that ING4 might be a tumor suppressor gene | breast, |
| Frequent deletion and decreased mRNA expression of ING4 suggested it as a class two tumor suppressor gene and may play an important role in head and neck cancer. | HNSC, |
| These results sustain the view that ING4 is a tumor suppressor in breast cancer and suggest that ING4 deletion may contribute to the pathogenesis of HER2-positive breast cancer. | breast, |
| Inhibitor of growth 4 upregulation plus radiotherapy induced synergistic tumor suppression in SPC-A1 xenografts implanted in athymic nude mice. Thus, the restoration of inhibitor of growth 4 function might provide a potential strategy for non-small cell lung cancer radiosensitization. | lung, |
| Tumor suppressor ING4 inhibits estrogen receptor activity in breast cancer cells | breast, |
| The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF). | None |
| Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4. | None |
| ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. | None |
| data suggest that alternative splicing could modulate the activity of ING4 tumor suppressor protein | None |
| The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis. | None |
| The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes. | None |
| The dimeric structure and the bivalent recognition of H3K4me3 by the tumor suppressor ING4 suggests a mechanism for enhanced targeting of the HBO1 complex to chromatin. | None |
| A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis. | None |
| Functional impact of cancer-associated mutations in the tumor suppressor protein ING4. | None |
| The essential role of tumor suppressor gene ING4 in various human cancers and non-neoplastic disorders | None |