| SIRT6 inhibits glioma cell proliferation and colony formation in vitro and glioma cell growth in vivo in a PCBP2 dependent manner. SIRT6 inhibits PCBP2 expression through deacetylating H3K9ac and SIRT6 acts as a tumor suppressor in glioma. | colorectal,glioma, |
| These results support a hypothesis whereby RUNX2-mediated repression of the SIRT6 tumor suppressor regulates metabolic pathways that promote breast cancer progression | breast, |
| demonstrate that PKM2 deacetylation is integral to SIRT6-mediated tumor suppression and inhibition of metastasis. Additionally, reduced SIRT6 levels correlate with elevated nuclear acetylated PKM2 levels in increasing grades of hepatocellular carcinoma | liver, |
| SIRT6 as an important pancreatic ductal adenocarcinoma tumor suppressor | pancreatic, |
| research findings demonstrate that SIRT6 serves as a tumor suppressor via regulation of the NF-kappaB pathway, which could offer an innovative strategy to treat adrenocortical carcinoma. | adrenocortical, |
| SIRT6 is a tumor suppressor that regulates aerobic glycolysis in cancer cells. Strikingly, SIRT6 acts as a first-hit tumor suppressor, and lack of this chromatin factor leads to tumor formation even in nontransformed cells. | None |
| SIRT1 localizes to the promoters of several aberrantly silenced tumor suppressor genes whose DNA is hypermethylated | None |
| Thus, these results reveal that SUMOylation has an important role in regulation of Sirt6 deacetylation on H3K56, as well as its tumor suppressive activity. | None |
| SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2. | None |
| Evidence shows that SIRT6 overexpression or knockout in cells can result in different biological responses as tumor suppressor or promoter, depending on cell and tumor type. [review] | None |
| SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer. | skin, |
| SIRT6 functions as an oncogene in the epidermis. | None |