| demonstrate that the PI3K p110alpha is required for pancreatic ductal adenocarcinoma induced by oncogenic Kras. | pancreatic, |
| Breast cancers harboring oncogenic PIK3CA activate SGK3 signaling while suppressing Akt, indicative of oncogenic functions for both INPP4B and SGK3 in these tumors. | breast, |
| AT-rich interactive domain 2, p110alpha, p53, and beta-catenin protein expression in hepatocellular carcinoma and clinicopathologic implications. | liver, |
| Study demonstrates the oncogenic cooperation between PI3K and Yap pathways along liver carcinogenesis. The PIK3CA/Yap mouse represents an important preclinical liver tumor model. | liver, |
| BCR/ABL oncogene-induced PI3K signaling pathway leads to chronic myeloid leukemia pathogenesis by impairing immuno-modulatory function of hemangioblasts. | leukemia, |
| PIG3 plays an oncogenic role in papillary thyroid cancer by activating the PI3K/AKT/PTEN pathway. | thyroid, |
| NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling. | endometrial, |
| Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity. | breast, |
| Findings indicate inositol polyphosphate 5-phosphatase PIPP (INPP5J) as a suppressor of oncogenic phosphoinositide 3-kinase (PI3K)/AKT signaling in breast cancer. | breast, |
| SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway. | prostate, |
| Results show that oncogenic PIK3CA mutations in HER2/neu overexpressing uterine serous carcinoma cells are common and may constitute a major mechanism of resistance to trastuzumab. | uterine, |
| Potential role of O-GlcNAcylation and involvement of PI3K/Akt1 pathway in the expression of oncogenic phenotypes of gastric cancer cells in vitro. | gastric, |
| Genetic alterations of the PIK3CA oncogene in human oral squamous cell carcinoma in an Indian population. | oral |
| Oncogenic PI3Kalpha promotes multipotency in breast epithelial cells. | breast, |
| PIK3CA and MET may play an important role in oncogenesis of certain specific subtypes of head and neck cancer | HNSC, |
| The data establish oncogenic PIK3CA mutations as a cause of glutamine dependency in colorectal cancer and suggest that targeting glutamine metabolism may be an effective approach to treat patients harboring PIK3CA mutations. | colorectal, |
| The data establish oncogenic PIK3CA mutations as a cause of glutamine dependency in colorectal cancer. | colorectal, |
| phenotypic changes in metabolism following a single copy knock-in of mutant PIK3CA (H1047R) in the MCF10A cell line, an important cell model for studying oncogenic transformation in breast tissues, were examined. | breast, |
| Data suggest a critical role for KDM3A in the PI3K/AP-1 oncogenic axis and propose a novel strategy for inhibition of KDM3A against liver tumor development under PI3K pathway activation. | liver, |
| Study showed for the first time that co-occuring oncogenic HER2 and mutant PIK3CA could induce replication stress in mammary epithelial cells and drives breast cancer progression. | breast, |