| Oncogenic PIK3CA alters methionine and cysteine utilization, partly by inhibiting xCT to contribute to the methionine dependency phenotype in human breast cancer cells. | breast, |
| The PIK3CA and PIK3R1 impactful mutations exhibit a mutually exclusive pattern, leading to oncogenesis and hyperactivity of PI3K pathway in breast cancer. | breast, |
| We assessed the genomic landscape of canine hemangiosarcoma via whole-exome sequencing (47 golden retriever hemangiosarcomas) and RNA sequencing (74 hemangiosarcomas from multiple breeds). Somatic coding mutations occurred most frequently in the tumor suppressor TP53 (59.6% of cases) as well as two genes in the PI3K pathway: the oncogene PIK3CA (29.8%) and its regulatory subunit PIK3R1 (8.5%). | sarcoma, |
| PIK3CA is implicated as an oncogene in ovarian cancer. | ovarian, |
| Concomitant activation of the PI3K-Akt and the Ras-ERK signaling pathways is essential for transformation by the V-SEA tyrosine kinase oncogene. | None |
| Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway. | None |
| PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling. | None |
| data suggest that mutant PIK3CA is likely to function as an oncogene in human cancers; PIK3CA may prove useful for diagnostic and therapeutic purposes | None |
| Oncogenic mutations of PIK3CA in human cancers. | None |
| oncogenic mutations in human cancers | None |
| Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance. | None |
| Oncogenic PI3K deregulates transcription and translation. | None |
| Oncogenic PI3K and its role in cancer. | None |
| A mutation status profile of the PIK3Ca gene in the National Cancer Institute (NCI)-60 panel of human cancer cell lines provides insights into the role of mutant PIK3Ca in oncogenic signaling | None |
| Cancer-specific mutations in PIK3CA are oncogenic in vivo. | None |
| PIK3CA mutations are oncogenic in chickens | None |
| Mutation of the PIK3CA oncogene in human cancers. | None |
| The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. | None |
| Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. | None |
| Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. | None |