| Prep1 has a tumor suppressor function in mice. Prep1(i/i) hypomorphic mice develop spontaneous tumors or pretumoral lesions, and transplantation of Prep1(i/i) fetal liver cells into lethally irradiated normal mice induces lymphomas. | lymphoma,liver, |
| The tumor suppressor role of Prep1 is associated with the maintenance of genomic stability. | None |
| deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesis | None |
| the replication timing of a specific fraction of the human genome is affected by PREP1 tumor suppressor | None |