| PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells | colorectal, |
| Results suggest that Plk1 is important for early embryonic development and may function as a haploinsufficient tumor suppressor. | None |
| Molecular targeting of the oncoprotein PLK1 in pediatric acute myeloid leukemia: RO3280, a novel PLK1 inhibitor, induces apoptosis in leukemia cells. | leukemia,pediatric, |
| PLK1 overexpression in prostate epithelial cells triggers oncogenic transformation. The signaling mechanisms underlying the observed cellular effects of PLK1 involve direct PLK1-dependent phosphorylation of CRAF with subsequent stimulation of the MEK1/2-ERK1/2-Fra1-ZEB1/2 signaling pathway. | prostate, |
| Inhibition of Plk1 activity suppresses pX-mediated oncogenic transformation. | None |
| In contrast to the addiction of many cancer cell lines to the non-oncogene Plk1, primary cell proliferation, spindle assembly and apoptosis exhibit only a low dependency on Plk1. | None |
| Data show that a microRNA-mimic to increase miR-34a together with siRNA to silence PLK1 oncogene prolonged survival. | None |
| these results suggest that the oncogenicity of BEX4 is conferred by PLK1-mediated phosphorylation, and thus, the BEX4-PLK1 interaction is a novel oncogenic signal that enables the acquisition of chromosomal aneuploidy. | None |