Sentence and cancer type
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SentenceCancertype
This study showed that expression of ectopic ATRX triggers a suppression of the pathway and telomere shortening.unknown
data suggest that the presence of ATRX at telomeres may have a central role in suppressing deleterious DNA secondary structures that form at transcribed telomeric repeats, and this may account for the increased DNA damage, stalling of replication and homology-directed repair previously observed upon loss of ATRX functionunknown
XRCC1 silencing suppressed lethal fusion of dysfunctional telomeres by allowing IDH1-mutant ATRX-deficient cells to use homologous recombination.unknown