| cDNA cloning; the hPB1 gene is located on chromosome 3p21, where the tumor suppressor genes for breast, lung and kidney cancers have been mapped | breast,lung,kidney, |
| The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer. | lung, |
| BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer. | breast, |
| PBRM1 could block the G2/M transition by repressing cyclin B1. The data indicated that PBRM1 functions as a tumor suppressor in bladder cancer by repressing cyclin B1 expression. | bladder, |
| PBRM1 might involve in the development and progression of breast cancer as a tumor suppressor, and thereby may be a valuable prognostic marker for breast cancer patients. | breast, |
| Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma | kidney, |
| SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer | kidney, |
| Re: Inactivation of the PBRM1 Tumor Suppressor Gene Amplifies the HIF-Response in VHL(-/-) Clear Cell Renal Carcinoma | kidney, |
| High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1 | None |
| Study identified PBRM1 as a reader for p53 acetylation on lysine 382 (K382Ac) through its bromodomain 4 (BD4). Mutations on key residues of BD4 disrupt recognition of p53 K382Ac and reduces p53 binding to promoters of target genes such as CDKN1A (p21). PBRM1 BD4 mutant fails to fully support p53 transcriptional activity and is defective as a tumor suppressor. | None |