| findings indicate tumor suppressor protein PP2A and its inhibitor CIP2A are widely distributed in meningiomas with a tendency for higher CIP2A expression in at least some higher-grade meningiomas; findings raise the possibility that CIP2A may participate in biology of meningiomas | meningiomas, |
| Activation of the Tumor Suppressor PP2A Emerges as a Potential Therapeutic Strategy for Treating Prostate Cancer | prostate, |
| The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. | None |
| These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA. | None |
| the dynamic nuclear distribution of the B56gamma3 regulatory subunit controls nuclear PP2A activity, which regulates cell cycle controllers, such as p27, to restrain cell cycle progression, and may be responsible for the tumor suppressor function of PP2A | None |
| Data reveal that the tumour suppressor PP2A may act via S369 to regulated NEDD9-mediated cell spreading. | None |
| Potential role for inhibition of protein phosphatase 2A tumor suppressor in salivary gland malignancies | None |
| NNMT Silencing Activates Tumor Suppressor PP2A, Inactivates Oncogenic STKs, and Inhibits Tumor Forming Ability | None |
| Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1 | None |
| Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56 | None |
| Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth | None |
| Ppp2r5d knockout mice are predisposed to spontaneous tumor development, providing the first in vivo evidence that validates a single PP2A complex as a bona fide tumor suppressor. | None |
| Evidence for PPP2R4 as a haploinsufficient tumor suppressor gene, defining a high-penetrance genetic mechanism for PP2A inhibition in human cancer. | None |
| The tumor suppressor phosphatase PP2A-B56? regulates stemness and promotes the initiation of malignancies in a novel murine model | None |
| Developmental and light regulation of tumor suppressor protein PP2A in the retina | None |
| Targeted therapies don_t work for a reason; the neglected tumor suppressor phosphatase PP2A strikes back | None |
| The present work identifies RABL6A as a new inhibitor of the PP2A tumor suppressor and an essential activator of AKT in PNET cells. Our findings offer what we believe is a novel strategy of PP2A reactivation for treatment of PNETs as well as other human cancers driven by RABL6A overexpression and PP2A inactivation. | None |
| Select Stabilization of a Tumor-Suppressive PP2A Heterotrimer | None |
| ApoE and apoE-mimetic peptides antagonize SET nuclear oncogene/inhibitor of protein phosphatase 2A (PP2A), increase cellular PP2A phosphatase activity, and decrease activation of inflammatory signal transduction pathways. | None |