| MEG3 inhibits colony formation in meningioma cells. MEG3 stimulates p53-mediated transactivation in these cell lines. Data are consistent with the hypothesis that MEG3 may be a tumor suppressor gene at chromosome 14q32 involved in meningioma progression. | colorectal, |
| This review indicated that MEG3 may have a significant role as a novel long noncoding RNA tumour suppressor in meningiomas. | meningiomas, |
| Data support the hypothesis that MEG3 is a lncRNA tumor suppressor in the pituitary and its inactivation contributes to clinically non-functioning pituitary adenomas development. | pituitary, |
| causing inhibition of proliferation and increased apoptosis in cervical cancer cells. In summary, our findings indicate that MEG3 function as a tumor suppressor by regulating miR-21-5p, resulting in the inhibition of tumor growth in cervical cancer. | cervical, |
| our study for the first time demonstrated that MEG3 was a tumor suppressor by negatively regulating the activity of the Wnt/beta-catenin pathway in the progression of retinoblastoma | retinoblastoma, |
| Results show that MTHFD1 is down-regulated in nasopharyngeal carcinoma (NPC) with a mechanism involving DNA copy number loss and promotor methylation. MEG3 seems to suppress cell proliferation and tumorigenicity suggesting it as a novel tumor suppressive lncRNA in NPC. | nasopharyngeal,laryngeal, |
| MEG3 was a promising tumor suppressor that may upregulate MTSS1 through the miR-96-5p pathway, subsequently suppressing the growth and metastasis of glioma. | glioma, |
| Tumor-Suppressive Function of lncRNA-MEG3 in Glioma Cells by Regulating miR-6088/SMARCB1 Axis | glioma, |
| Deregulated expression of the imprinted DLK1-DIO3 region in Glioblastoma Stem-like Cells: tumor suppressor role of lncRNA MEG3 | glioblastoma, |
| MEG3 non-coding RNA may function as a tumor suppressor, whose action is mediated by both p53-dependent and p53-independent pathways | None |
| Therefore, these data are consistent with the hypothesis that MEG3, which encodes a noncoding RNA, may be a tumor suppressor gene at chromosome 14q32 involved in meningioma progression via a novel mechanism. | None |
| The DLK1-MEG3 locus plays a tumor suppressor role in human nonfunctioning adenomas. | None |
| In this review, author summarized the gene as tumor suppressor in table 2. | None |
| MEG3 noncoding RNA: a tumor suppressor. | None |
| MEG3 noncoding RNA: a tumor suppressor. These lines of evidence strongly suggest that MEG3 functions as a novel lncRNA tumor suppressor. | None |
| our results suggest that the lncRNA Meg3 acts as a tumor suppressor in EOC by regulating ATG3 activity and inducing autophagy. | None |
| MEG3 acts as a tumor suppressor by negatively regulating the activity of the PKM2 and beta-catenin signaling pathway in hepatocarcinogenesis. | None |
| Long noncoding RNA MEG3 is a tumor suppressor in choriocarcinoma by upregulation of microRNA-211 | None |
| Maternally expressed gene 3 (MEG3): A tumor suppressor long non coding RNA | None |