| Data indicate that miR-449a is a miRNA component of the Rb pathway and its tumor suppressor-like effects, in part, depends on Rb status in prostate cancer cells. | prostate, |
| Results suggest that miR-449a may act as a tumor suppressor by targeting CDC25A in endometrial cancer. | endometrial, |
| microRNA-449 family acts as a tumor suppressor in liver cancer by causing cell death and inhibiting cell migration. These effects are caused by downregulation of the oncogene SOX4. | liver, |
| miR-449a functions as a tumor suppressor in NSCLC by targeting the HMGB1-mediated NF-kappaB signaling pathway in NSCLC. | lung, |
| MicroRNA-449a functions as a tumor suppressor in pancreatic cancer by the epigenetic regulation of ATDC expression | pancreatic, |
| reveals a tumor suppressor function of miR-449a/b through regulating Rb/E2F1 activity, and suggests that escape from this regulation through an aberrant epigenetic event contributes to E2F1 deregulation and unrestricted proliferation in human cancer | None |
| The tumor suppression role of microRNA-449a could be due to its promotion of tumor cell proliferation and its inhibition of tumor cell apoptosis. | None |
| The tumor suppressor functions of miR-449a in GC involve the inhibition of cell proliferation, induction of G0/G1 arrest and apoptosis by directly targeting E2F3. | None |
| MiR-449a, a candidate tumor suppressor gene regulated by hypermethylation, is a novel potential epigenetic marker for WNT subtype of medulloblastoma. | None |
| Findings define an oncogenic function of miR-449a in human breast cancer, and highlight the importance of this pathway in driving aggressive behaviour. | breast, |