| CACNA2D3 is a novel tumor suppressor gene responsible for the 3p21 deletion event that plays a critical suppressing role in the development and progression of esophageal squamous cell carcinoma. | esophageal, |
| Findings demonstrate the tumor suppressive role of CACNA2D3 in gliomas. CACNA2D3 operates via Ca 2thorn signaling and the activation of non-canonical Wnt signaling to inhibit cell proliferation and motility and induce apoptosis. | glioma, |
| Results found that CACNA2D3 was lowly expressed in endometrial cancer (EC) tissues and cells. Its overexpression significantly blocked the tumor growth in an in vivo xenograft model while in vitro, it inhibited cell proliferation and migration, and promoted apoptosis and calcium influx. These data revealed that CACNA2D3 functions as a tumor suppressor in EC. | endometrial, |