Sentence and cancer type
Showing 1-7 of 7 items.
SentenceCancertype
vascular smooth muscle cell apoptosis proceeds through a pathway that involves PKCdelta, the intermediary p38 MAPK, and the downstream target tumor suppressor p53None
PKC-delta inhibits transformed keratinocyte growth by inducing apoptosis, and may function as a tumor suppressor in human SCCs where its loss in cells harboring activated ras could provide a growth advantage by conferring resistance to apoptosisNone
Regulation of tumor suppressor PDCD4 by novel protein kinase C isoforms.None
Data indicate that all deltaWT tumors had activating mutations in KRAS, whereas only 69% of deltaKO tumors did, suggesting that PKCdelta acts as a tumor promoter downstream of oncogenic K-ras while acting as a tumor suppressor in other oncogenic contexts.None
Protein kinase C acts as a tumor suppressor.Cancer-associated mutations in protein kinase C are generally loss-of-function mutations.[review]None
Tumor suppressor activity of Protein kinase C-delta.[review]None
Role of oncogenes and tumor suppressor genes in multistage carcinogenesis.None