| Both genetic (gene deletion) and epigenetic alterations (promoter methylation) are likely mechanisms that inactivate the putative tumor suppressor AJAP1 in gliomas, which contributes to poor prognosis. | glioma, |
| Article summarizes and discusses current knowledge that may identify AJAP1 as a tumor suppressor in gliomas. [Review] | glioma, |
| This study demonstrated that AJAP1 acted as a putative tumor suppressor while beta-catenin nuclear localization positively fed back on EGF/EGFR-attenuated AJAP1 expression in breast cancer, which might be beneficial to develop new therapeutic targets for decreasing nuclear beta-catenin-mediated malignancy in breast cancer. | breast, |
| Alternative exon usage creates novel transcript variants of tumor suppressor SHREW-1 gene with differential tissue expression profile | None |