| SMURF1 amplification promotes invasiveness in pancreatic cancer. | pancreatic, |
| SMURF1 is an amplified oncogene driving multiple tumorigenic phenotypes in pancreatic cancer | pancreatic, |
| CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation. | colorectal, |
| these findings demonstrate a novel mechanism of interplays for the different branches of ER stress signaling network and highlight IRAK2 as a potential tumor suppressor to counterbalance oncogenic Smurf1. | None |