| Heterozygous mutations in the tumor suppressor gene PATCHED provoke basal cell carcinoma-like features in human organotypic skin cultures. | skin, |
| Authors report a loss-of-function mutation of PTCH1, a tumor suppressor in the Hh pathway, in a colorectal cancer that exhibits transcriptional upregulation of the downstream Hh gene GLI1. | colorectal, |
| results suggest that the Ptc tumour suppressor functions normally as a transmembrane molecular transporter, which acts indirectly to inhibit Smo activity | None |
| Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9. | None |
| Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. | None |
| Identification and characterization of multiple isoforms of a murine and human tumor suppressor, patched, having distinct first exons. | None |
| The CDK inhibitor p18Ink4c is a tumor suppressor in medulloblastoma. | None |
| Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling. | None |
| These data support a tumor suppressor gene role for PTCH1 in nonsyndromic or sporadic CFs. | None |
| Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. | None |
| Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice. | None |
| preeminence of Ptch1 as a tumor suppressor in cerebellar granule cells | None |
| Assessment of Promoter Methylation Identifies PTCH as a Putative Tumor-suppressor Gene in Human CLL | None |
| Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma | None |
| Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice. | thyroid, |
| Correspondence re: G. Tallini et al., RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotype. Clin. Cancer Res., 4:287-294, 1998. | thyroid, |
| Detection of RET/PTC oncogene rearrangements in Korean papillary thyroid carcinomas. | thyroid, |
| Translocation t(10;14)(q11.2:q22.1) fusing the kinetin to the RET gene creates a novel rearranged form (PTC8) of the RET proto-oncogene in radiation-induced childhood papillary thyroid carcinoma. | thyroid, |
| RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho. | thyroid, |
| The RET/PTC oncogene is frequently activated in oncocytic thyroid tumors (Hurthle cell adenomas and carcinomas), but not in oncocytic hyperplastic lesions. | thyroid, |