| The GRHL3-PTEN axis is a critical tumor suppressor pathway in squamous cell carcinoma. | None |
| Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells. | None |
| Data suggest that hDlg may serve as a platform to bring in proximity APC and PTEN tumor suppressor activities. | None |
| SUMO1 modification is required for PTEN tumour suppressor function by controlling PTEN membrane association and regulation of the phosphatidylinositol-3 kinase/AKT pathway. | None |
| study demonstrates that in the Drosophila lymph gland the tumor suppressors TSC and PTEN control blood progenitor proliferation through a common TOR- and 4EBP-dependent pathway | None |
| data suggest that EZH2 is overexpressed in B-ALL and promotes the progression of B-ALL by directly mediating the inactivation of tumor suppressor genes p21 and PTEN | None |
| The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells. | None |
| MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase. | None |
| loss of the tumor suppressor PTEN disrupts cell rearrangements by preventing the lengthening of newly formed junctions that become unstable and keep on rearranging | None |
| Two different groups have demonstrated that PTEN is secreted/exported into the extracellular environment for uptake by recipient cells, and functions as a tumor suppressor in a cell non-autonomous manner. | None |
| PIASxalpha is a novel SUMO E3 ligase for PTEN, and it positively regulates PTEN protein level in tumor suppression. | None |
| miR-200a functions as an oncogene, affecting proliferation and apoptosis by regulating the expression of the tumor suppressor PTEN at the translational level. | None |
| An enhanced engineered PTEN dramatically represses PIP3 signaling with increased tumor suppressor activities. | None |
| Results provide evidence that p62 contributes to HER2-induced mammary tumorigenesis through multiple signaling pathways and provide insights into its potential role in the regulation of the tumor suppressor PTEN. | None |
| mechanistic studies disclosed that EBV-miR-BART7-3p targeted a major human tumor suppressor PTEN, modulating PI3K/Akt/GSK-3beta signaling | None |
| PTEN is a potent tumor suppressor in human salivary gland tumors, and targeting PI3K/mTOR pathway may be effective in the targeted therapy for human SGT patients with loss of PTEN expression. | None |
| SMYD2-mediated methylation negatively regulates PTEN tumor suppressor activity and results in activation of the phosphatidylinositol 3-kinase-AKT pathway. | None |
| Potential compensatory indels were identified in two tumor suppressor genes, TP53 and PTEN, where compensatory indels are composed of frameshift indels that can recover the original reading frame. | None |
| PTEN noncatalytic missense mutation exposes a core tumor suppressor function distinct from inhibition of canonical AKT signaling that predisposes to organ-selective cancer development in vivo | None |
| We conclude that one mechanism by which lncRNAs function in in tumorigenesis is as ceRNAs for tumor suppressor mRNAs. | None |