| LMP1-mediated NF-kappaB can up-regulate DNMT3b transcription, thereby leading to relatively higher methylation intensity at PTEN CpG islands, and ultimately silencing major tumor suppressor PTEN | None |
| Data show that miR-4534 exerts its oncogenic effects partly by downregulating the tumor suppressor PTEN gene. | None |
| In particular, AQP8 affected VEGF-induced redox signaling by increasing the sulfenation of the tumor suppressor PTEN, which resulted in its inactivation and, in turn, caused Akt activation | None |
| Studies indicate complex PTEN-cooperating tumor suppressor networks in different cancer types, with potential clinical implications. | None |
| PTEN-long tumor suppressor can repress cancer glial cells proliferation. | None |
| Star-PAP-specific polyadenylation sites usage regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppressor gene PTEN and the long non-coding RNA NEAT1. | None |
| Through the characterization of the interactomes of APE1 with RNA and other proteins, we demonstrate here a role for APE1 in pri-miRNA processing and stability via association with the DROSHA-processing complex during genotoxic stress. We also show that endonuclease activity of APE1 is required for the processing of miR-221/222 in regulating expression of the tumor suppressor PTEN. | None |
| MTSS1 is stabilized by the protein phosphatase activity of the tumor suppressor PTEN. Our data show that PTEN loss in PDAC cells results in both increased metastatic potential and decreased MTSS1 expression. Furthermore, we show that ectopic MTSS1 expression rescues this effect. | None |
| CFTR attaches tumor suppressor PTEN to the membrane and promotes anti Pseudomonas aeruginosa immunity. | None |
| DBP(n) are non-toxic to the cells and have a weak overall demethylation effect on genomic DNA. DBP(n) demethylate the promoter regions of the tumor suppressor genes PTEN and RARB. DBP(n) promotes expression of the genes RARB, PTEN, CDKN2A, RUNX3, Apaf-1 and APC silent in the MCF-7 because of the hypermethylation of their promoter regions | None |
| these results indicate that miR-21a negatively modulates two tumor suppressor genes, miR-200c and PTEN, thereby promoting M2 macrophage transformation | None |
| Study demonstrates that electrophilic 15d-PGJ2 directly binds to cysteine 136 of PTEN and provides new insight into PTEN loss in cancer progression associated with chronic inflammation. These observations suggest that 15d-PGJ2 can undergo nucleophilic addition to PTEN, presumably at Cys(136), thereby inactivating this tumor suppressor protein with concomitant Akt activation. | None |
| Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role | None |
| PTEN splice variant PTEN-Delta shows similar function as the tumor suppressor PTEN itself | None |
| PTEN: Tumor Suppressor and Metabolic Regulator | None |
| Bioinformatic studies showed that these two miRNAs target PTEN and DUSP14 tumor suppressor genes. Quantitative Real-time PCR confirmed the overexpression of the miRNAs and downregulation of their targets. Luciferase assay confirmed that the miRNAs target PTEN and DUSP14. | None |
| Peroxiredoxin III Protects Tumor Suppressor PTEN from Oxidation by 15-Hydroperoxy-eicosatetraenoic Acid | None |
| Identification and validation of mRNA 3_untranslated regions of DNMT3B and TET3 as novel competing endogenous RNAs of the tumor suppressor PTEN. | None |
| Discovery of the PTEN Tumor Suppressor and Its Connection to the PI3K and AKT Oncogenes | None |
| Redox regulation of tumor suppressor PTEN in cell signaling | None |