| [Pathogenic role of PTEN tumor suppressor gene in ovarian cancer associated to endometriosis]. | ovarian, |
| Loss of heterozygosity is an independent prognostic factor and PTEN is a candidate as a haploinsufficient tumor suppressor in gastric cancers. | gastric, |
| Epigenetic PTEN silencing seems to be a relevant mechanism of inactivating this tumor suppressor gene in melanoma that may promote melanoma development by derepression of the AKT pathway. | skin, |
| [Expression of tumor suppressor gene PTEN in laryngeal carcinoma and its clinical significance]. | laryngeal, |
| [Expression of tumor suppressor gene PTEN, PIP3 and cyclin D1 in oral squamous cell carcinoma and their correlations]. | oral |
| Our results indicate that Ad-PTEN exerts its tumor suppressive effect on bladder cancer cells through inhibiting survivin and upregulating caspase-related proteins. Thus Ad-PTEN may be potentially therapeutic for the treatment of bladder cancers. | bladder, |
| In conclusion, using a biologically relevant model system to dissect PTEN tumor suppressor function in human bladder cancer, we identified three molecules important for many cellular functions in complex with PTEN. | bladder, |
| Peroxisome proliferator-activated receptor gamma and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells. | leukemia, |
| transcriptional down-regulation of the tumor suppressor PTEN in pancreatic adenocarcinoma if facilitated by effect of K-RAS/ERK on TGFbeta | pancreatic, |
| MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. | liver, |
| Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients. | liver, |
| Pten is essential for both normal lung morphogenesis and the prevention of lung carcinogenesis, possibly because this tumor suppressor is required for bronchioalveolar stem cells homeostasis. | lung, |
| [Inhibitory effects of tumor suppressor gene PTEN on proliferation and metastasis of breast cancer ZR-75-1 cells]. | breast, |
| Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. | breast, |
| Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation. | glioma, |
| Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. | prostate, |
| These results support a model in which the PTEN tumour suppressor protein cooperates with pVHL to suppress cyst development in the kidney. | kidney, |
| [Expression of tumor suppressor gene pten in patients with myelodysplastic syndrome and acute myeloid leukemia]. | leukemia, |
| inactivation of GRP78 may represent a previously undescribed approach to stop prostate cancer and potentially other cancers resulting from the loss of PTEN tumor suppression and/or activation of the oncogenic AKT | prostate, |
| Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. | astrocytomas, |