| Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. | glioma, |
| Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer. | prostate, |
| Oncogenic BRaf (V600E) cooperates with silencing of the Pten tumor suppressor gene to induce metastatic melanoma in mouse models | skin, |
| The tumor suppressor protein PTEN inhibits rat hepatic stellate cell activation. | liver, |
| A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1. | prostate, |
| Defects in Notch-1 signaling may play a role in human prostate tumor formation in part via a mechanism that involves regulation of the PTEN tumor suppressor gene. | prostate, |
| Identified up-regulation of microRNA-21 (hsa-miR-21) concurrent with down-regulation of potent tumor suppressor proteins PTEN and programmed cell death 4 in cholesteatoma as compared with normal skin. | skin, |
| Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells. | glioma, |
| The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. | nasopharyngeal,laryngeal, |
| PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice. | leukemia, |
| Tumor suppressor phosphatase and tensin homolog PTEN is negatively regulated by miR-21 at post-transcriptional level via binding to 3_-untranslated region (UTR) of PTEN mRNA in non-small cell lung cancer cells. | lung, |
| Microarray data revealed that 153 genes were upregulated in DNMT3A knockdown cells; 13 of them including PTEN, a crucial tumor suppressor gene in HCC, are genes involved in cell cycle and cell proliferation. | liver, |
| Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway. | gastric, |
| we demonstrate that loss of the PTEN tumor suppressor gene, with associated activation of the PI3K/Akt/mTOR pathway, leads to a human glioma phenotype that induces autologous T-cell apoptosis upon contact | glioma, |
| PTEN and SHIP act cooperatively to suppress B cell lymphoma and provides the first direct evidence that SHIP is a tumor suppressor. | lymphoma, |
| Secondary mutations attenuated this tumor suppressor response in some leukemias that arose after Pten deletion | leukemia, |
| a known tumor suppressor in ovarian cancer. Confirmed that miR-21 was significantly overexpressed in human EOC tissues and cell lines. Demonstrated knockdown of miR-21 significantly increased PTEN expression, a known tumor suppressor in ovarian cancer. | ovarian, |
| Clinical significance of tumor suppressor PTEN in colorectal carcinoma. | colorectal, |
| Immunohistochemical phospho tensin tumor suppressor gene staining patterns in endometrial hyperplasias: a 2-year study. | endometrial, |
| identified concurrent mutational inactivation of the PTEN and RB1 tumor suppressors as a mechanism for loss of BRAF/MEK dependence in melanomas harboring (V600E)BRAF mutations | skin, |