| The decreased PTEN was associated with poorer survival outcomes of patients with kidney cancer and PTEN acts as a tumor suppressor in tumorigeneses and progression in kidney cancer. | kidney, |
| STX3 represses the stability of the tumor suppressor PTEN to activate the PI3K-Akt-mTOR signaling and promotes the growth of breast cancer cells | breast, |
| LASP1 promotes nasopharyngeal carcinoma progression through negatively regulation of the tumor suppressor PTEN | nasopharyngeal,laryngeal, |
| Study findings suggest a novel tumor suppressive role of Pten PDZ-binding domain (PDZ-BD) in a murine model of breast cancer, and the mechanism involves the dysregulation of homeobox genes which may result in defective myoepithelial differentiation in breast cancer cells. | breast, |
| MicroRNA-498 promotes proliferation and migration by targeting the tumor suppressor PTEN in breast cancer cells | breast, |
| Studies have indicated that in breast cancer, PTEN undergo mutations. There is a functional and mechanistic link between the BMI-1 oncoprotein and tumor suppressor PTEN in the development and progression of breast cancer. [review] | breast, |
| Findings support that NQO1 displays a paradoxical role in mediating GBM growth in response to tumor suppressor PTEN. | GBM, |
| GFRA2 was upregulated in human neuroblastoma cells and tissues, and promoted neuroblastoma cell proliferation through interacting with the tumor suppressor PTEN. | neuroblastoma, |
| RSRC1 knockdown promoted the proliferation and migration of gastric cancer cells. In addition, the knockdown of RSRC1 decreased the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a potent tumor suppressor gene controlling cellular growth and viability. | gastric, |
| The PTEN Tumor Suppressor Gene in Soft Tissue Sarcoma | sarcoma, |
| MicroRNA-590-5p promotes cell survival in endometrioid endometrial cancer by suppressing tumor suppressor PTEN | endometrial, |
| Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. | endometrial, |
| Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. | None |
| The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. | None |
| Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. | None |
| Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. | None |
| Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. | None |
| The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. | None |
| Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. | None |
| Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. | None |