| Germline and somatic mutations within PTEN_s ATP-binding domain influence its subcellular localization and tumor suppressive function. | None |
| Data show that Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 (PTEN and RECK) and miR-221 (p27). | None |
| The role of PDK1 in the pathology caused by deletion of the tumor suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN), is characterized. | None |
| show that miR-221&222, by targeting PTEN and TIMP3 tumor suppressors, induce TRAIL resistance and enhance cellular migration through the activation of the AKT pathway and metallopeptidases | None |
| Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. | None |
| Via a novel pathway involving tumor suppressor phosphatase and tensin homolog phosphatase (PTEN) inhibition, leptin promotes GluR1 trafficking to hippocampal synapses. | None |
| Redox regulation of the tumor suppressor PTEN by glutathione. | None |
| Findings define a tumor suppressor role for NHERF1 at the plasma membrane, and reveal a novel mechanism for PI3K/Akt activation through PTEN inactivation caused by a loss of membrane-localized NHERF1. | None |
| Alkylation of the tumor suppressor PTEN activates Akt and ??-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. | None |
| The PTEN tumor suppressor inhibits human airway smooth muscle cell migration. | None |
| Various studies have revealed the essential roles of these PTEN-targeting noncoding RNAs during tumor development, thus providing a paradigm to explore the molecular mechanisms underlying the dosage-dependent effects of key oncogenes and tumor suppressors | None |
| Data show that miR-183 has a potential oncogenic role through the regulation of 2 tumor suppressor genes, EGR1 and PTEN, and the deregulation of this fundamental miRNA regulatory network may be central to many tumor types. | None |
| Redox regulation of the tumor suppressor PTEN by glutaredoxin 5 and Ycp4. | None |
| role of post-translational modification of PTEN in host tumor suppressor functions; possibility of antineoplastic therapy using drugs that regulate post-translational modification of PTEN [REVIEW] | None |
| Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells. | None |
| these results provide further support for the existence of a DNA damage-inducible size checkpoint that is regulated by a major tumor suppressor, and they provide a novel Akt-independent mechanism by which PTEN controls cell size. | None |
| show for the first time a significant disruption of all three members of the PTEN-NHERF1-PHLPP1 tumor suppressor network in high-grade tumors, correlating with Akt activation and patient_s abysmal survival | None |
| while PTEN inactivation alone has a minimal effect on intestinal homeostasis, it can facilitate tumor promotion upon deregulation of beta-catenin/TCF signaling, further establishing PTEN as a bona fide tumor suppressor gene in intestinal cancer. | None |
| Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. | None |
| Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. | None |