| Identify miR-146b-5p as a tumor suppressor and novel prognostic biomarker of gliomas, and suggest miR-146b-5p and TRAF6 as potential therapeutic candidates for malignant gliomas. | glioma, |
| miR-146b expression is downregulated in prostate tumor tissues and may be a potential tumor suppressor miR. | prostate, |
| our data demonstrated that miR146b5p, as a tumor suppressor, mediated temozolomide resistance in GBM cells through negatively regulating TRAF6 expression, indicating that miR146b5p and its targeted genes would be potential therapeutic targets for glioma therapy. | GBM,glioma, |
| MiR-146b-5p acts as tumor suppressor in osteosarcoma.P16INK4a regulates the expression of miR-146b-5p in osteosarcoma.TRAF6 is a direct target of miR-146b-5p. | osteosarcoma, |
| MicroRNA miR-146b-5p regulates signal transduction of TGF-beta by repressing SMAD4 in thyroid cancer. | thyroid, |
| Our results confirm the oncogenic role of miR-146b-5p in thyroid follicular cells and contribute to knowledge regarding the modulation of TGF-beta signal transduction by miRNAs in PTCs. | thyroid, |
| miR-146a enhances the oncogenicity of oral carcinoma by concomitant targeting of the IRAK1, TRAF6 and NUMB genes. | oral |