| our study demonstrates that miR-506 may act as a tumor suppressor in gastric cancer(GC) and that the miR-506/Yap1 axis may help us better understand the molecular mechanisms of GC progression. | gastric, |
| miR-506 functions as a tumor suppressor miRNA in nasopharyngeal carcinoma; its suppressive effects are mediated chiefly by repressing FOXQ1 expression. | nasopharyngeal,laryngeal, |
| the present study is the first to provide evidence that miR-506 acts as a tumor suppressor, at least partially, by directly downregulating IQGAP1 in breast cancer cells. | breast, |
| findings collectively suggest that miR-506 acts as a tumor suppressor via regulation of ROCK1 expression and may thus be a promising therapeutic target for HCC | liver, |
| MiR-506 functions as a tumor suppressor in glioma by targeting STAT3 | glioma, |
| Bioinformatics analysis and luciferase reporter assay revealed that NEAT1 directly bound to the miR-506-3p, which has been reported to act as a tumor suppressor in diverse cancers. the tumor-promoting effects of NEAT1 in pancreatic cancer cells is at least partly through negative modulation of miR-506-3p. | pancreatic, |
| miR-506 acts as a tumor suppressor and inhibits malignancy of colorectal cancer cells through directly targeting LAMC1. | colorectal, |
| These findings expand the known mechanisms of MIR506-mediated tumor suppression to activation of autophagy-related cell death and suggest a strategy for using MIR506 as an anti-STAT3 approach to Pancreatic ductal adenocarcinoma treatment. | pancreatic, |
| miR-506 functions as a tumor suppressor miRNA and plays a significant role in inhibiting human mantle cell lymphoma cell proliferation and metastasis by suppressing B7H3 expression. | lymphoma, |
| miR-506 is a YAP1-dependent tumor suppressor in laryngeal squamous cell carcinoma | laryngeal, |
| MiR-506 may function as a tumor suppressor and targets and inhibits Zeb2 in gastric carcinoma. | gastric, |
| MiR-506-3p acts as a novel tumor suppressor in prostate cancer through targeting GALNT4. | prostate, |
| rescue experiments using MTMR6 overexpression further verified that MTMR6 was a functional target of miR-506-3p. Our data indicate that miR-506-3p might serve as a tumor suppressor gene and propose a new regulatory mechanism of MTMR6 by miR-506-3p in ovarian cancer . | ovarian, |
| investigation into role of MIR506 as an anti-oncogene: expression of MIR506 is reduced in transformed malignant cells compared to normal bronchial epithelial cells; MIR506 seems to negatively regulate expression of N-Ras gene in lung cancer cells | lung, |
| A novel oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation and promoting melanoma growth. | skin, |