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Cancertype
The PTK6 plays a tumor suppressor role in laryngeal squamous cell carcinoma (LSCC) by regulating c-myc and cyclinD1 expression, cell apoptosis, EMT and MMP-9.
laryngeal,
These results provide evidence for a novel mechanism demonstrating the oncogenic potential of PTK6 through degradation of c-Cbl, which is an E3 ligase important in down-regulation of oncoproteins.
None