| Deregulation of the tumor suppressor HACE1 is associated with natural killer/T-cell lymphoma, nasal type. | lymphoma, |
| HACE1 is tumor suppressor gene located within the 6q21 region, and loss of function of multiple tumor suppressor genes within 6q21 may be a critical determinant of NK cell lymphomagenesis. | lymphoma, |
| HACE1 can act as a haploinsufficient tumor suppressor gene in most B-cell lymphomas and can be downregulated by deacetylation of its promoter region chromatin | lymphoma, |
| Tumor-suppressive role of HACE1 in hepatocellular carcinoma and its clinical significance | liver, |
| Ectopic expression of HACE1 markedly inhibited anchorage-independent growth and cell motility of HACE1 osteosarcoma cell lines, HACE1 overexpression blocked osteosarcoma xenograft growth and dramatically reduced pulmonary metastases. These findings point to a potential tumor suppressor function for HACE1 in osteosarcoma. | osteosarcoma, |
| The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. | None |
| HACE1 controls TNF-elicited cell fate decisions and exerts tumor suppressor and anti-inflammatory activities via a TNFR1-RIP3 kinase-necroptosis pathway. | None |
| The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate | None |
| Loss of the Tumor Suppressor HACE1 Contributes to Cancer Progression | None |