| Findings implicate PTPN1 as a tumor suppressor gene in Primary mediastinal B-cell lymphoma and classical Hodgkin lymphoma and suggest that loss of PTPN1 phosphatase activity may promote the development of these cancers. | lymphoma, |
| PTP1B has a tumor suppressor function in myeloid lineage cells.PTP1B deficiency leads to shorter lifespan and the development of acute leukemia. | leukemia, |
| we demonstrated a novel oncogenic mechanism of PTP1B on affecting PITX1/p120RasGAP in colorectal carcinoma(CRC). Regorafenib inhibited CRC survival through reserving PTP1B-dependant PITX1/p120RasGAP downregulation. PTP1B may be a potential biomarker predicting regorafenib effectiveness, and a potential solution for CRC | colorectal, |
| results highlight that PTP1B is an oncogene and is negatively regulated by miR-338-3p in Gastric cancer (GC), which may provide new insights into novel molecular therapeutic targets for GC. | gastric, |