| differential gene expression of Bard1, a tumor suppressor gene, plays a significant role in the proliferation of breast cancer | breast, |
| Fine mapping of 2q35 high-risk neuroblastoma locus reveals independent functional risk variants and suggests full-length BARD1 as tumor-suppressor | neuroblastoma, |
| Functional characterization of full-length BARD1 strengthens its role as a tumor suppressor in neuroblastoma | neuroblastoma, |
| It is structurally homologous to BRCA1 (it shares the conserved RING finger and BRCT domains); may be involved in tumor suppression because BARD1-BRCA1 complexes in ubiquination of RNA Pol II and BARD1 interacts with CstF-50 (inhibiting mRNA processing). | None |
| Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells. | None |
| Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair. | None |
| The remarkable similarities between the mammary carcinomas of Bard1-, Brca1-, and Bard1/Brca1-mutant mice indicate that the tumor suppressor activities of both genes are mediated through the BRCA1/BARD1 heterodimer. | None |
| BRCA1-BARD1 mutants with weakened RAD51 interactions show compromised DNA joint formation and impaired mediation of homologous recombination and DNA repair in cells; results identify a late role of BRCA1-BARD1 in homologous recombination, an attribute of the tumour suppressor complex that could be targeted in cancer therapy | None |
| we discuss recent advances in elucidating the mechanisms by which BRCA1-BARD1 functions in DNA repair, replication fork maintenance and tumour suppression, and its therapeutic relevance. | None |
| our findings identify BARD1beta as an oncogenic driver of high-risk neuroblastoma tumorigenesis | neuroblastoma, |
| Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome. | colorectal, |
| Oncogenic BARD1 isoforms expressed in gynecological cancers. | None |