| Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element | None |
| A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression. | prostate, |
| the GG genotype of SNP rs13281615 plays a role in breast cancer likely by influencing PVT1 expression, and that during oncogenesis, protective mutations could occur. | breast, |
| Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma. | mesothelioma, |
| we found that PVT1 functioned as an oncogene and may be a crucial prognostic factor for NSCLC patients. PVT1 contributed to lung adenocarcinoma cell proliferation, partly though EZH2-medicated suppression of the LATS2/MDM2/P53 pathway. | lung, |
| results indicate that PVT1 functions as an oncogene in melanoma and could be a potential diagnostic biomarker and therapeutic target for melanoma. | skin, |
| PVT1 may be a new oncogene co-amplified with c-Myc in colorectal cancer tissues and extracellular vesicles and functionally correlated with the proliferation and apoptosis of colorectal cancer cells. | colorectal, |
| PVT1 has a higher expression levels in HCC tissues than that in the adjacent normal tissues, and functions as an oncogene by promoting HCC cell proliferation, invasion. Furthermore, we found that PVT1 interacted with EZH2 repressed miR-214 expression in HCC cells | liver, |
| PVT1 played an oncogenic role in prostate cancer | prostate, |
| Data suggest that long noncoding RNA PVT1 may be an oncogene as well as may promote metastasis in clear cell renal cell carcinoma (ccRCC) and could serve as a potential biomarker to predict the prognosis of ccRCC patients. | kidney, |
| We found that circPVT1 behaves as an oncogene in HNSCC and that the mut-p53/YAP/TEAD complex transcriptionally regulates its expression. | HNSC, |
| PVT1 knockdown could negatively regulate miR-424 to inhibit cellular activity, migration, and invasiveness in human gliomas, which explained the oncogenic mechanism of PVT1 in human gliomas. It also suggested that PVT1 might be a novel therapeutic target for human gliomas. | glioma, |
| The findings of the present study illustrated that Circular RNA PVT1 , working as an oncogene, promotes metastasis via miR-145 sponging in colorectal cancer. | colorectal, |
| PVT1 exerts an oncogenic role through activating Wnt/ss-catenin signaling in pituitary adenoma cells. | pituitary, |
| Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC. | None |
| PVT1 has a role in competing endogenous RNA activity and regulation of protein stability of important oncogenes, primarily of the MYC oncogene [review] | None |
| PVT1: a rising star among oncogenic long noncoding RNAs. | None |
| Studies on the association between PVT1 and cancer have shown that PVT1 is a potential oncogene in a variety of cancer types. [review] | None |