| Our results represent the first successful demonstration of a tumor suppressor function for the cohesin complex (consisting of Rad21, Smc1a, Smc3, and Stag2 proteins), while also confirming that cohesin mutations occur as an early event in leukemogenesis, facilitating the potential development of a myeloid malignancy. | leukemia |
| They included the well-described oncogenic driver genes for the 17q12 amplicon, ERBB2 and GRB7. Four of six other candidate driver genes-RAD21 and EIF3H, both on chromosome 8q23, CHRAC1 on chromosome 8q24.3 and TANC2 on chromosome 17q23-were confirmed to be driver genes regulating the proliferation/survival of clonogenic breast cancer cells presenting an amplification of the corresponding region. | breast |
| RAD21 suppression enhances the antitumor activity of chemotherapeutic agents acting via induction of DNA damage | unknown |