| Knockdown of HSF1 with shRNA induced the protein expression of tumor suppressor retinoblastoma protein, resulting in attenuated plc/prf5 cell growth and colony formation in vitro. | colorectal,retinoblastoma, |
| PRMT4 has a role in arginine methylation, which negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation | retinoblastoma, |
| Authors found that retinoblastoma tumor suppressor knockdown prior to infection impaired human cytomegalovirus lytic infection at multiple stages, notably viral DNA replication, late protein expression, and infectious virion production. | retinoblastoma, |
| In pancreatic neoplasms, miR-137 targets KDM4A mRNA during Ras-induced senescence and activates both p53 and retinoblastoma (pRb) tumor suppressor pathways. | pancreatic,neoplasm,retinoblastoma, |
| The maternally inherited c.1981C>T/p.Arg661Trp RB1 allele retains sufficient tumor suppressor activity to prevent retinoblastoma development. | retinoblastoma, |
| Cytokeratin-19 (CK-19)+ specific deletion of tumor suppressors p53 and Retinoblastoma (Rb) indicated that carcinomas at the injury site originates from cholangiocytes or liver progenitor cells. | liver,retinoblastoma, |
| our data highlights an unprecedented role for OCT4 as central regulator of mitotic fidelity and retinoblastoma tumor suppressor pathway activity | retinoblastoma, |
| In mouse hepatocytes, p38gamma induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. Lack of p38gamma or treatment with the p38gamma inhibitor pirfenidone protects against the chemically induced formation of liver tumours. | liver,retinoblastoma, |
| Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse. | retinoblastoma, |
| Retinoblastoma, a tumor suppressor, is a coactivator for the androgen receptor in human prostate cancer DU145 cells. | prostate,retinoblastoma, |
| Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system. | None |
| PML-RARalpha alleviates the transcriptional repression mediated by tumor suppressor Rb. | None |
| Oxidized low density lipoprotein induces the cyclin-dependent kinase inhibitor p21(waf1) and the tumor suppressor Rb. | None |
| employs both canonical cyclin-dependent kinase/cyclin regulation and metabolic regulation as a means to limit proliferation, underscoring its potency in tumor suppression | None |
| Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription. | None |
| These results indicate that PAI-2 may enhance Rb_s tumor suppressor activity and suggest a potential therapeutic role for PAI-2 against HPV-transformed lesions. | None |
| kinetic framework of RB tumor suppressor action in transcriptional repression and cell cycle regulation | None |
| controls cell proliferation, differentiation, and senescence and provides an essential tumor suppressive function that cells must eliminate to attain unlimited proliferative potential | None |
| Docking-dependent regulation of the Rb tumor suppressor protein by Cdk4. | None |
| The Rb tumor suppressor is required for stress erythropoiesis. | None |