| Direct and indirect effects of the pRb tumor suppressor on autophagy. | None |
| Cancerous tissues from 30 patients with HPSCC were examined for LOH in 4 tumor suppressor genes (TSGs) (p16, Rb, E-cadherin, and p53) at loci 9p21, 13q21, 6q22, and 17p13, respectively, using microsatellite markers amplified by polymerase chain reaction. | None |
| Results reveal a functional connection between the pRB and Hippo tumor suppressor pathways, and suggest that low levels of LATS2 may undermine the ability of pRB to induce a permanent cell cycle arrest in tumor cells. | None |
| Rb encodes a tumor suppressor that attenuates progression of oncogenic Kras-induced carcinogenesis in the pancreas by mediating the senescence response and promoting activity of the tumor suppressor p53. | None |
| downstream effectors of the p53-p21 and p16-pRB tumour suppressor pathways crucial for mediating entry into senescence | None |
| Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation. | None |
| The LXCXE binding motif has an essential role in RB-mediated transcriptional control, response to genotoxic insult, and tumor suppression. | None |
| the cooperative effect of inactivation of both pRB and p53 tumor suppressor pathways promotes Whole chromosome instability | None |
| CXCR7 expression is sufficient to drive post-confluent growth in endothelial cell cultures. We provide a novel mechanism for CXCR7-mediated proliferation via proteasomal degradation of the tumor suppressor protein Rb. | None |
| p21, in conjunction with pRb, has a central role in regulating multiple epithelial processes and orchestrating specific tumor suppressor functions | None |
| Carcinoma initiation via RB tumor suppressor inactivation: a versatile approach to epithelial subtype-dependent cancer initiation in diverse tissues | None |
| Cyclin D has a role in activating the Rb tumor suppressor by mono-phosphorylation | None |
| co-transcription of ncRNA-RB1 and RB1 provides a positive link between the expression of the two tumor suppressors RB1 and the immune-relevant CALR protein | None |
| Ras induces the formation of a complex between NORE1A and the phosphatase PP1A, promoting the activation of the Rb tumor suppressor by dephosphorylation | None |
| Results suggest that RB1 is the dominant tumor suppressor PP in MCC, and that inactivation of RB1 by MCPyV-LT is largely sufficient for its growth supporting function in established MCPyV-positive MCC cells. | None |
| Increased the expression of tumor suppressor genes such as Cdkn2A, Rb1 and p53. | None |
| The Rb1 tumor suppressor gene modifies telomeric chromatin architecture by regulating TERRA expression. | None |
| Overexpression of TRAF3 in HPV(+) cell lines with decreased endogenous TRAF3 inhibited NF-kappaB2/RELB expression, nuclear localization, and NF-kappaB reporter activity, while increasing the expression of IFNA1 mRNA and protein and sensitizing cells to its growth inhibition. Overexpression of TRAF3 also enhanced TP53 and RB tumor suppressor proteins and decreased HPV E6 oncoprotein in HPV(+) cells | None |
| Tumor suppressor gene expression during normal and pathologic myocardial growth. | None |
| Tumor suppressor gene mutations in mice. | None |