Sentence and cancer type
Showing 401-420 of 577 items.
SentenceCancertype
Change in the spectrum of RET mutations diagnosed between 1994 and 2006. None
a change in the spectrum of mutations detected in the RET proto-oncogene in patients with hereditary MTC from the _classical_ mutation at codon 634 in exon 11 (level 2) to more cases with mutations in the exons 13-15 (level 1) and less aggressive diseaseNone
[The clinical patterns and RET proto-oncogene in fifteen multiple endocrine neoplasia type 2A pedigrees]. None
Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene. None
[DelD631: a novel mutation of the RET proto-oncogene in multiple endocrine neoplasia type 2A (MEN2A)]. None
RET proto-oncogene testing in infants presenting with Hirschsprung disease identifies 2 new multiple endocrine neoplasia 2A kindreds. None
[Mutation of the RET proto-oncogene in type 2A multiple endocrine neoplasia Chinese families and the application of pentagastrin stimulation test in diagnosis and follow-up]. None
Uncommon association of germline mutations of RET proto-oncogene and CDKN2A gene. None
Oncogenic RET mutations may, however, vary between specific population groups. RET analysis in MEN has revolutionized the management of children of MEN2 and allowed surgical prediction and prophylaxis to take place.None
The RET proto-oncogene has become the target for molecularly designed drug therapy. Tyrosine kinase inhibitors targeting activated RET are currently in clinical trials for the treatment of patients with MTC.None
Enhanced sensitivity of the RET proto-oncogene to ionizing radiation in vitro. None
XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway. None
Analysis of RET, ZEB2, EDN3 and GDNF genomic rearrangements in 80 patients with Hirschsprung disease (using multiplex ligation-dependent probe amplification). None
Genetic testing for multiple endocrine neoplasia type 2. None
Missense mutations in RET proto-oncogene correlated with pathology and diagnosis of Multiple endocrine neoplasia type 2 carriersNone
Genetic testing is essential in patients with confirmed MTC, and should be extended to all first degree relatives when a RET proto-oncogene mutation is discovered. Early prophylactic surgery is the definitive treatment for carriers of RET mutations.None
Mutations in the RET proto-oncogene is associated with multiple endocrine neoplasia type 2A.None
The ret oncogene products are membrane-bound glycoproteins phosphorylated on tyrosine residues in vivo. None
A TaqI RFLP in the human ret proto-oncogene. None
Molecular analyses revealed an oncogenic potential for all the novel germline RET variants. The prevalence of exon 8 genomic variations with an oncogenic potential may be higher than previously thought.None