| miR-486 may function as a novel tumor-suppressor miRNA in gastric cancer. Its antioncogenic activity may involve the direct targeting and inhibition of OLFM4. | gastric, |
| miR-486 directly targets components of insulin growth factor (IGF) signaling including IGF1, IGF1 receptor, and phosphoinositide-3-kinase, regulatory subunit 1alpha (PIK3R1, or p85a) and functions as a potent tumor suppressor of lung cancer. | lung, |
| Direct repression of the oncogene CDK4 by the tumor suppressor miR-486-5p in non-small cell lung cancer | lung, |
| Downregulated miR-486-5p acts as a tumor suppressor in esophageal squamous cell carcinoma | esophageal, |
| Study revealed that miR-486 was downregulated in esophageal squamous carcinoma and functions as a tumor suppressor by affecting cell proliferation, colony formation and apoptosis by targeting CDK4 and BCAS2. | colorectal,esophageal, |
| MicroRNA?486?5p functions as a tumor suppressor of proliferation and cancer stem?like cell properties by targeting Sirt1 in liver cancer | liver, |
| MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1 | oral |
| miR-486-5p acts as an oncogene in the progression of NSCLC by influencing PTEN-PI3 K/AKT signaling | lung, |