Sentence and cancer type
Showing 1-7 of 7 items.
SentenceCancertype
Gain- and loss-of-function studies in vitro and in vivo validated GOLPH3 as a potent oncogeneNone
Because cytokinesis failures have been associated with premalignant disease and cancer, our studies suggest novel insight into molecular circuits involving the oncogene GOLPH3 in cytokinesisNone
An oncogenic protein Golgi phosphoprotein 3 up-regulates cell migration via sialylation. None
The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis. None
The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3. None
In this review, we will explore the cellular functions regulated by GOLPH3 and discuss if and how they contribute to the oncogenic activity of this intriguing Golgi localized oncoprotein.None
Proteomic-based screens identified GOLPH3 as a resident protein of the Golgi apparatus, and second as an oncogene product in a screen for genes amplified in cancer. A third screen uncovered the association of GOLPH3 with the Golgi resident phosphatidyl inositol 4 phosphate to maintain the characteristic ribbon structure of the Golgi apparatus favoring vesicular transport of secretory proteins. [review]None