| These results indicated that MKK4 acts as a tumor suppressor and may represent an important therapeutic target for the treatment of ovarian cancer | ovarian, |
| Analysis of the mitogen-activated protein kinase kinase 4 (MAP2K4) tumor suppressor gene in ovarian cancer. | ovarian, |
| Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor ??2 expression. | lung, |
| Study provides evidence that phosphorylated MKK4 (pMKK4) might function as a tumor suppressor in colorectal cancer (CRC). Downregulation of pMKK4 was associated with a more aggressive phenotype and with increases in local invasion and metastasis. pMKK4 was also strongly associated with disease-free survival. | colorectal, |
| Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. | pancreatic,breast, |
| Disruption of MKK4 signaling reveals its tumor suppressor role in embryonic stem cells. | None |
| Negative regulation of JNK signaling by the tumor suppressor CYLD. | None |
| Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. | None |