| SFRP2 gene is a high-frequent target of epigenetic inactivation in human breast cancer; its methylation leads to abrogation of SFRP2 expression, conferring a growth advantage to epithelial mammary cells; this supports a tumor suppressive function of SFRP2 | breast, |
| The role of SFRP2, as a functional tumor suppressor in the development of oral squamous cell carcinoma, is mediated through inhibition of the Wnt signaling pathway. | oral |
| KRAS, BRAF oncogene mutations and tissue specific promoter hypermethylation of tumor suppressor SFRP2, DAPK1, MGMT, HIC1 and p16 genes in colorectal cancer patients | colorectal, |
| Findings demonstrated that SFRP2 was downregulated in pituitary corticotroph adenomas. SFRP2 appears to act as a tumor suppressor in Cushing_s disease by regulating the activity of the Wnt signaling pathway. | pituitary, |
| LUCAT1 Epigenetically Downregulates the Tumor Suppressor Genes CXXC4 and SFRP2 in Gastric Cancer | gastric, |