| SRSF3 was frequently upregulated in clinical glioma specimens and was associated with tumor progression and poor prognosis. SRSF3 expression promoted cell proliferation, self-renewal, and tumorigenesis. Transcriptomic profiling found more than 1,000 SRSF3-affected alternative splicing events. SRSF3-regulated AS of ETV1 and NDE1 markedly increased their oncogenic activity in GSCs. | glioma, |
| Studied association of hnRNP L Alternative Exon 7 and serine and arginine rich splicing factor 3 (SRSF3) in head and neck squamous cell carcinoma(HNSCC); found inclusion of hnRNP L alternative exon 7 is associated with good prognosis and inhibited by oncogene SRSF3 in HNSCC. | HNSC, |
| SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance. | None |
| Data suggest that the oncogenic potential of SRSF3 might be realized, in part, through the translational repression of PDCD4 mRNA. | None |