| results not only reveal novel insights into how Skp2 SCF complex is regulated, but also establish a new role for Foxo3a in tumor suppression through a transcription-dependent and independent manner | None |
| SKP2 plays an oncogenic role in lung cancer and that SKP2 silencing may be useful in the treatment of lung cancer | lung, |
| FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2. | breast, |
| SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells. | leukemia, |
| Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium. | oral |
| Stat3 induces oncogenic Skp2 expression in human cervical carcinoma cells. | cervical, |
| Targeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agent. | breast,prostate, |
| Authors observed an inverse correlation between Skp2 and E-cadherin expression in clinical breast tumor samples. Therefore, our work elucidates a novel acetylation-dependent regulatory mechanism for Skp2 oncogenic functions. | breast, |
| The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells. | breast, |
| The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth. | prostate, |
| this study uncovering Skp2-mediated Twist stabilization and oncogenic functions in castration-resistant prostate cancer (CRPC) offers new knowledge on how CRPC progresses and acquires chemoresistance during tumor progression | prostate, |
| Hippo-Yap signaling suppresses liver cell polyploidy and oncogenesis through Skp2. | liver, |
| Skp2 exhibited an oncogenic function in osteosarcoma cells. | osteosarcoma, |
| Skp2 is oncogenic and overexpressed in human cancers. | None |
| The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin 1- and Skp2-containing E3 ligase. | None |
| Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway. | None |
| Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. | None |
| SKP2 is a direct MYC target gene and that MYC-mediated SKP2 induction leads to reduced p27 levels. The results suggest the induction of SKP2 oncogene as a new mechanism for MYC-dependent transformation | None |
| Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2. | None |
| The overexpression of miR5085p was able to downregulate the expression of the SKP2 oncogene, through a mechanism by which miR5085p directly targeted the SKP2 gene. | None |