| Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143 | breast, |
| C/EBPalpha-p30 protein induces expression of the oncogenic long non-coding RNA UCA1 in acute myeloid leukemia. | leukemia, |
| Data indicate that an oncogenic long non-coding RNA UCA1 functioning in concert with the dominant negative isoform of 30-kDa dominant negative isoform CCAAT/enhancer-binding protein-alpha (C/EBPalpha-p30) in acute myeloid leukemia (AML). | leukemia, |
| UCA1 can directly interact with miR-143, lower its expression and affect its downstream regulation. The UCA1-miR-143 axis constitutes a part of the oncogenic role of UCA1 in breast cancer. | breast, |
| Conclude that UCA1 functions as an oncogene in non-small cell lung carcinoma, acting mechanistically by upregulating ERBB4 in part through _spongeing_ miR-193a-3p. | lung, |
| LncRNA-UCA1 exerts oncogenic functions in non-small cell lung cancer by targeting miR-193a-3p. | lung, |
| Ectopic overexpression and gene silencing of UCA1 in renal cell carcinoma cell lines had opposite effects on cellular proliferation, migration and apoptosis, and the results suggested that UCA1 may function as an oncogene in renal cell carcinoma. | kidney, |
| lncRNA UCA1 was an independent prognostic biomarker of disease-free survival in gastric cancer patients and acted as an oncogene to regulate the malignant proliferation and resistance to adriamycin in gastric cancer cells. | gastric, |
| pivotal role of UCA1 in the oncogenesis of oral squamous cell carcinoma and reveal a novel LncRNA UCA1-beta-catenin-WNT signaling pathway regulatory network that could contribute to our understanding in the pathogenesis of OSCC and assist in the discovery of a viable LncRNA-directed diagnostic and therapeutic strategy for this fatal disease | oral |
| UCA1 down-regulation inhibited cell proliferation and migration in both SKMES-1 and H520 lung cancer cells. This study demonstrated that UCA1 exerts oncogenes activity in lung cancer, acting mechanistically by upregulating HMGB1 expression through _sponging_ miR-193a. | lung, |
| Study showed a highly expressed UCA1 in adrenocortical cancer (AC) patients. Its overexpression facilitated the growth of ACC cells, which suggested the potential oncogenic function of UCA1 in ACC. Furthermore, the molecular study uncovered that UCA1 sponged miR-298 and up-regulated CDK6, which indicated that critical involvement of miR-298-CDK6 pathway in mediating the promoting effect of UCA1 on the growth of ACC cells. | adrenocortical, |
| our research revealed that UCA1 works as an oncogene by targetting miR-204. The UCA1-miR-204-CXCR4 regulatory network regulated the growth and metastasis of Prostate cancer (PCa) , providing new insight in the management of patients with such malignancy. | prostate, |
| Long non-coding RNA urothelial carcinoma associated 1 induces cell replication by inhibiting BRG1 in 5637 cells. | None |
| UCA1 functions as an oncogenic lncRNA in several malignancies, and it might become a potential biomarker or therapeutic target for human cancers | None |
| The migration and invasion capacities of PC cells were suppressed by UCA1. siRNA was then enhanced by the miR-135a inhibitor. In vivo, UCA1 siRNA effectively suppressed tumor growth and the expression of migration markers. Taken together, our research revealed that UCA1 works as an oncogene by targeting miR-135a. | None |