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Sentence	Cancertype
Study suggest that HLTF functions as a tumor suppressor gene in colorectal cancer (CRC). HLTF downregulation promotes the migration and invasion of CRC cells in vitro. Furthermore, HLTF expression is negatively associated with overall survival in patients with CRC. HLTF may suppress the migration and invasion of CRC cells by targeting TGFbeta/SMAD signaling.	colorectal,
HLTF can promote error-free replication of damaged DNA and support a role for HLTF in preventing mutagenesis and carcinogenesis, providing thereby for its potential tumor suppressor role.	None