Sentence and cancer type
Showing 21-34 of 34 items.
SentenceCancertype
inhibition of migration is another crucial tumor suppressor function of hSNF5/INI1, in addition to its previously described functions in proliferation and differentiationNone
Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.None
Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors.None
INI1 is the primary tumor suppressor gene involved in the development of rhabdoid tumors with no second locus identified.None
Loss of the SNF5 tumor suppressor leads to elevated expression of the Polycomb gene EZH2.None
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.None
MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformationNone
the cytoplasmic Snr1 may play a tumor suppressive role in Drosophila imaginal tissues.None
MARCB1 deficiency induced GEFs for Rac GTPase activation and augmented AML cell migration and survival. Collectively, these findings highlight tumor suppressor role of SMARCB1 and illustrate SWI/SNF(Delta) function in maintaining an oncogenic gene expression program in AML.None
Modulating the Expression Strength of the Baculovirus/Insect Cell Expression System: A Toolbox Applied to the Human Tumor Suppressor SMARCB1/SNF5None
Loss of SMARCB1 tumor suppressor function is a key oncogenic event in epithelioid malignant peripheral nerve sheath tumors.None
Tumor suppressor SMARCB1 suppresses super-enhancers to govern hESC lineage determinationNone
Inhibition of MYC by the SMARCB1 tumor suppressorNone
Study identifies SWINGN, a lncRNA interacting with SMARCB1 exclusively in proliferating conditions, exerting a pro-oncogenic role in some tumor types. SWINGN is transcribed from an enhancer and modulates the activation of GAS6 oncogene as part of a topologically organized region, as well as a larger network of pro-oncogenic genes by favoring SMARCB1 binding.None