| Tumor DNA showed loss of heterozygosity (LOH) of the wild-type allele or a second inactivating mutation as a second hit in some tumors, implying a tumor suppressor function of the SMARCE1 gene. | meningiomas |
| These findings establish SMARCE1 is a critical oncogenic factor in neuroblastoma and provide a new potential target for treatment of neuroblastoma with 17q21-ter gain and MYCN amplification. | neuroblastoma |
| mutations in BAF57 could impinge on several oncogenic signaling pathways contributing to the origin and/or development of breast cancer. | breast |
| BAF57-mediated cell death is associated with up-regulation of proapoptotic genes including the tumor suppressor familial cylindromatosis (CYLD), which is found to be a direct target of BAF57. | cylindromatosis |