| risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 | breast,ovarian, |
| BRCA1 is a tumor suppressor gene and is known to be responsible for breast cancer and breast-ovarian cancers running in families. | breast,ovarian, |
| These observations are consistent with the idea that BRCA2, but not BRCA1, is a tumor suppressor of prostate cancer. | prostate, |
| Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner. | prostate, |
| High confluency of human adipose stromal cells cultured in vitro can significantly stimulate aromatase gene expression and reduce the expression of breast tumor suppressor BRCA1 and members of the NR4A orphan nuclear family. | breast, |
| HOXA9 restricts breast tumor aggression by modulating expression of the tumor suppressor gene BRCA1 | breast, |
| Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection. | breast, |
| Data indicate that pathogenic mutations were found in 13/47 (28%) ovarian cancers: eight in BRCA1 and five in BRCA2 tumor suppressor proteins. | ovarian, |
| Homozygous nonsense mutations in the tumor suppressor gene BRCA1 is associated with breast and ovarian cancer. | breast,ovarian, |
| Alteration of BRCA-1 tumor suppressor gene expression in serous and mucinous ovarian neoplasms in the benign-borderline-malignant pathway. | neoplasm,ovarian, |
| Individual deletion of Palb2, Brca1 or Brca2 genes in pancreas per se using Pdx1-Cre was insufficient to cause tumors, but it reduced pancreata size. Concurrent expression of mutant KrasG12D and p53R270H, with tumor suppressor inactivated strains in Palb2-KPC, Brca1-KPC or Brca2-KPC, accelerated pancreatic ductal adenocarcinoma (PDAC) development. | pancreatic, |
| Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation. | None |
| Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. | None |
| The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. | None |
| solution properties of the highly conserved C terminus of BRCA1, consisting of a tandem repeat of the BRCT domain (BRCT-tan), that plays a critical role in BRCA1-mediated tumor suppression | None |
| Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor. | None |
| Tumor suppressor gene BRCA-1 is expressed by embryonic and adult neural stem cells and involved in cell proliferation. | None |
| Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability. | None |
| Functions as a tumor suppressor in other epithelia in addition to the mammary gland. | None |
| Structure-function analysis of proposed domains and motifs for known activity of TdT reveals nonessential role for tumor suppressor BRCA1 C-terminal (BRCT) domain and essential roles for second helix-hairpin-helix motif and entire C terminus of TdT. | None |